Post-ictal analgesia in genetically epilepsy-prone rats is induced by audiogenic seizures and involves cannabinoid receptors in the periaqueductal gray

► Audiogenic seizures (AGS) induce post-ictal analgesia (PIA) in GEPRs. ► AGS-induced post-ictal analgesia lasted for ≥ 120 min after seizure. ► The periaqueductal gray (PAG) is critical for PIA in GEPRs. ► Microinjection of a CB1 antagonist into PAG blocked PIA in GEPRs. ► This is the first observation of post-ictal analgesia in a genetic form of epilepsy.