Effects of estrogen and aging on the synaptic distribution of phosphorylated Akt-immunoreactivity in the CA1 region of the female rat hippocampus

► pAkt is present in both terminals and spines in CA1, and is particularly abundant in the postsynaptic density. ► synaptic pAkt is decreased in aged female rats. ► estradiol treatment increases synaptic pAkt in both young and aged rats, but the increase is less pronounced in aged rats..