Effects of 5-hydroxytryptamine on substantia gelatinosa neurons of the trigeminal subnucleus caudalis in immature mice

► The majority of SG neurons in the Vc are hyperpolarized by 5-HT. ► 5-HT has postsynaptic actions on SG neurons. ► K+ channel, 5-HT1A and 5-HT2 receptors are involved in 5-HT-induced hyperpolarization.