The effect of Na+/H+ exchanger-1 inhibition by sabiporide on blood-brain barrier dysfunction after ischemia/hypoxia in vivo and in vitro

►Sabiporide attenuates ischemia/hypoxia-induced BBB hyperpermeability. ►Sabiporide attenuates ischemia/hypoxia-induced TJ disruption. ►BBB protection by sabiporide may be mediated by [Ca2+]i overload under hypoxia.