Evidence that obesity and androgens have independent and opposing effects on gonadotropin production from puberty to maturity

►Obesity appears to suppress luteinizing hormone (LH) levels from puberty onwards. ►Moderate testosterone elevation appears to stimulate LH production in women. ►LH output in polycystic ovary syndrome depends on obesity-androgen balance. ►Obesity appears to advance the onset of pubertal LH secretion.