کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4326423 1614082 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Olfactory deficit detected by fMRI in early Alzheimer's disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Olfactory deficit detected by fMRI in early Alzheimer's disease
چکیده انگلیسی

Alzheimer's disease (AD) is accompanied by smell dysfunction, as measured by psychophysical tests. Currently, it is unknown whether AD-related alterations in central olfactory system neural activity, as measured by functional magnetic resonance imaging (fMRI), are detectable beyond those observed in healthy elderly. Moreover, it is not known whether such changes are correlated with indices of odor perception and dementia. To investigate these issues, 12 early stage AD patients and 13 nondemented controls underwent fMRI while being exposed to each of three concentrations of lavender oil odorant. All participants were administered the University of Pennsylvania Smell Identification Test (UPSIT), the Mini-Mental State Examination (MMSE), the Mattis Dementia Rating Scale-2 (DRS-2), and the Clinical Dementia Rating Scale (CDR). The blood oxygen level-dependent (BOLD) signal at primary olfactory cortex (POC) was weaker in AD than in HC subjects. At the lowest odorant concentration, the BOLD signals within POC, hippocampus, and insula were significantly correlated with UPSIT, MMSE, DRS-2, and CDR scores. The BOLD signal intensity and activation volume within the POC increased significantly as a function of odorant concentration in the AD group, but not in the control group. These findings demonstrate that olfactory fMRI is sensitive to the AD-related olfactory and cognitive functional decline.

Research highlights
► Olfactory BOLD signals to different odor concentrations are significantly reduced in AD.
► BOLD signals in AD are significantly correlated with UPSIT, MMSE, DRS-2, and CDR.
► Olfactory BOLD signal changes dynamically during fMRI paradigm due to habituation.
► Pattern of such dynamic change differs significantly between AD and normal groups.
► BOLD signal and its dynamic patterns due to habituation differentiate AD from normal controls.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1357, 21 October 2010, Pages 184–194
نویسندگان
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