Cyclothiazide induces seizure behavior in freely moving rats

►In this study, we demonstrated cyclothiazide as a potent convulsant to induce seizure behavior: ►Cyclothiazide dose-dependently induced acute seizure behavior in freely moving rats; ►Cyclothiazide induced seizure behavior is associated with typical epileptiform EEG ►Diazepam pretreatment prevented cyclothiazide to induce seizure behavior occurring.