Strong somatic stimulation differentially regulates the firing properties of prefrontal cortex neurons

►Somatic stimulation (paw pinch) decreases prefrontal cortical spontaneous firing. ►Somatic stimulation (paw pinch) increases prefrontal cortical depolarization-evoked firing. ►Systemic administration of DAD2 antagonists partially blocks the effects of somatic stimulation in PFC. ►Systemic administration of D1 antagonists seem to facilitate paw pinch mediated increases in evoked firing.