کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4326893 1614100 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A potential role for adiponectin receptor 2 (AdipoR2) in the regulation of alcohol intake
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
A potential role for adiponectin receptor 2 (AdipoR2) in the regulation of alcohol intake
چکیده انگلیسی

The anterior cingulate cortex (ACC) has been implicated in alcohol and drug addiction. We recently identified the small G protein K-ras as an alcohol-regulated gene in the ACC by gene expression analysis. We show here that the adiponectin receptor 2 (AdipoR2) was differentially regulated by alcohol in the ACC in a K-ras-dependent manner. Additionally, withdrawal-associated increased drinking was attenuated in AdipoR2 null mice. Intracellular recordings revealed that adiponectin increased the excitability of ACC neurons and that this effect was more pronounced during alcohol withdrawal, suggesting that AdipoR2 signaling may contribute to increased ACC activity. Altogether, the data implicate K-ras-regulated pathways involving AdipoR2 in the cellular and behavioral actions of alcohol that may contribute to overactivity of the ACC during withdrawal and excessive alcohol drinking.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1339, 21 June 2010, Pages 11–17
نویسندگان
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