کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4326920 | 1614109 | 2010 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Slow age-dependent decline of doublecortin expression and BrdU labeling in the forebrain from lesser hedgehog tenrecs
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کلمات کلیدی
-immunoreactivitypaleocortexTBSGADβIII-TubulinPBSDcx5-bromo-2′-deoxyuridine - 5-bromo-2'-deoxyuridineBrdU - بروموداکسی اوریدینTris-buffered saline - تریس بافر شورdoublecortin - دوچرخهdentate gyrus - شکنج دندانه دارPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریadult neurogenesis - نوروژنز بزرگسالان-ir - وParv - پاروParvalbumin - پاروالبومینolfactory bulb - پیاز بویاییcarbocyanine - کاربوسیانینCalb - کالباسCalretinin - کالورتینینcalbindin - کلبیندینGlutamate decarboxylase - گلوتامات دکربوکسیلاز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Slow age-dependent decline of doublecortin expression and BrdU labeling in the forebrain from lesser hedgehog tenrecs Slow age-dependent decline of doublecortin expression and BrdU labeling in the forebrain from lesser hedgehog tenrecs](/preview/png/4326920.png)
چکیده انگلیسی
In addition to synaptic remodeling, formation of new neurons is increasingly acknowledged as an important cue for plastic changes in the central nervous system. Whereas all vertebrates retain a moderate neuroproliferative capacity, phylogenetically younger mammals become dramatically impaired in this potential during aging. The present study shows that the lesser hedgehog tenrec, an insectivore with a low encephalization index, preserves its neurogenic potential surprisingly well during aging. This was shown by quantitative analysis of 5-bromo-2â²-deoxyuridine (BrdU) immunolabeling in the olfactory bulb, paleo-, archi-, and neocortices from 2- to 7-year-old animals. In addition to these newly born cells, a large number of previously formed immature neurons are present throughout adulthood as shown by doublecortin (DCX) immunostaining in various forebrain regions including archicortex, paleocortex, nucleus accumbens, and amygdala. Several ventricle-associated cells in olfactory bulb and hippocampus were double-labeled by BrdU and DCX immunoreactivity. However, most DCX cells in the paleocortex can be considered as persisting immature neurons that obviously do not enter a differentiation program since double fluorescence labeling does not reveal their co-occurrence with numerous neuronal markers, whereas only a small portion coexpresses the pan-neuronal marker HuC/D. Finally, the present study reveals tenrecs as suitable laboratory animals to study age-dependent brain alterations (e.g., of neurogenesis) or slow degenerative processes, particularly due to the at least doubled longevity of tenrecs in comparison to mice and rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1330, 12 May 2010, Pages 9-19
Journal: Brain Research - Volume 1330, 12 May 2010, Pages 9-19
نویسندگان
Alán Alpár, Heinz Künzle, Ulrich Gärtner, Yulia Popkova, Ute Bauer, Jens Grosche, Andreas Reichenbach, Wolfgang Härtig,