کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4326959 1614103 2010 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Collateral projection from the forebrain and mesopontine cholinergic neurons to whisker-related, sensory and motor regions of the rat
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Collateral projection from the forebrain and mesopontine cholinergic neurons to whisker-related, sensory and motor regions of the rat
چکیده انگلیسی

The primary goal of this anatomical study was to examine in the rat whether cholinergic neurons provide axon collaterals to whisker-related, sensorimotor regions at cortical, thalamic, and brainstem levels, using a combined method of retrograde tracing and choline acetyltransferase (ChAT) immunostaining. First, when injections were made at primary sensory (S1) barrel field/primary whisker motor (M1) cortices, cholinergic neurons with dual projections were observed in the basal nucleus of Meynert (BM), mainly at middle level; the projection was almost exclusively ipsilateral (99% ± 0.7%, n = 6). Second, following unilateral injections of tracers into ventroposteromedial (VPM) barreloids/ventrolateral (VL) thalamic nucleus, dual-projecting cells were observed in the mesopontine tegmental complex including the pedunculopontine tegmental (PTg) and laterodorsal tegmental (LDTg) nuclei, mainly at rostral to middle levels; the projection exhibited ipsilateral dominance, i.e., 67% ± 1.3% (n = 6) for the PTg and 64% ± 1.2% (n = 6) for the LDTg. Finally, when injections were made at whisker-related, principal sensory trigeminal (Pr5)/facial motor (Mo7) nuclei, a relatively small number of labeled neurons were observed in the PTg and the LDTg at middle to caudal levels; within LDTg, labeled cells occupied the ventral portion of the dorsal LDTg as well as the ventral LDTg (LDTgV). This projection exhibited contralateral preponderance, i.e., 67% ± 2.0% (n = 6) for the PTg and 69% ± 3.2% (n = 6) for the LDTg. Taken together, the present observations demonstrated that each division of the BM, PTg, and LDTg possessed a differential functional organization with respect to its collateral projection to whisker-related sensorimotor targets, suggesting that the cholinergic projection might play a modulatory role in vibrissal sensorimotor integration, which allows the guidance of behavioral action essential for the survival of the animal.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1336, 8 June 2010, Pages 30–45
نویسندگان
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