کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4326965 | 1614103 | 2010 | 5 صفحه PDF | دانلود رایگان |
14-3-3 proteins comprise a large family of highly conserved, acidic polypeptides, expressed in all eukaryotic organisms, with highest concentration found in the brain. Multiple isoforms of 14-3-3 proteins have been shown to play an essential role in regulating differentiation, proliferation and transformation. In the previous study, the expression levels of all seven 14-3-3 isoforms were examined in astrocytoma. However, the expression of seven 14-3-3 isoforms in meningioma still remains unknown. This study is the first examination of 14-3-3 isoforms in three grades of meningioma by immunohistochemistry. 14-3-3ε, ζ and θ were specifically expressed in meningioma, and their expression levels increased with the increase of pathological grade of meningioma. The 14-3-3 η, β, γ and σ isoforms were negatively expressed in meningioma. In conclusion, The 14-3-3 ε, ζ and θ may be involved in tumorigenesis of meningioma and be efficient markers for predicting the degree of malignancy in meningioma.
Journal: Brain Research - Volume 1336, 8 June 2010, Pages 98–102