کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4327250 1614117 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spinal GABA receptors mediate the suppressive effect of electroacupuncture on cold allodynia in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Spinal GABA receptors mediate the suppressive effect of electroacupuncture on cold allodynia in rats
چکیده انگلیسی
This study was performed to determine whether spinal GABAergic systems mediate the relieving effects of low frequency electroacupuncture (EA) on cold allodynia in a rat tail model of neuropathic pain. For neuropathic surgery, the right superior caudal trunk was resected at the level between the S1 and S2 spinal nerves innervating the tail. Two weeks after the nerve injury, the intrathecal catheter was implanted. Five days after the catheterization, rats were intrathecally injected with gabazine (GABAA receptor antagonist, 0.0003, 0.001 or 0.003 μg), or saclofen (GABAB receptor antagonist, 3, 10 or 30 μg). Ten minutes after the injection, EA (2 Hz) was applied to the ST36 acupoint for 30 min. The cold allodynia was assessed by the tail immersion test (i.e. immersing the tail in cold (4 °C) water and measuring the latency of an abrupt tail movement) before and after the EA treatment. EA stimulation at ST36 significantly inhibited the cold allodynia sign, whereas EA at non-acupoint and plain acupuncture at ST36 (without electrical stimulation) did not show antiallodynic effects. Intrathecal administration of gabazine or saclofen blocked the relieving effects of ST36 EA stimulation on cold allodynia. These results suggest that spinal GABAA and GABAB receptors mediate the suppressive effect of low frequency EA on cold allodynia in the tail neuropathic rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1322, 31 March 2010, Pages 24-29
نویسندگان
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