کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4327279 1614121 2010 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Altered local coherence in the default mode network due to sevoflurane anesthesia
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Altered local coherence in the default mode network due to sevoflurane anesthesia
چکیده انگلیسی

Recently we introduced a robust measure, integrated local correlation (ILC), of local connectivity in the brain using fMRI data which reflects the temporal correlation of brain activity in every voxel neighborhood. The current work studies ILC in fMRI data obtained in the absence and presence of sevoflurane anesthesia (0%, 2%, and 1% end-tidal concentration, respectively) administered to healthy volunteers. ILC was determined specifically in regions of the default mode network (DMN) to address local changes in each state. In addition, a potential confound in analyses based on correlations due to signal-to-noise variations was addressed by wavelet denoising. This accommodated decreases in signal power commonly seen during anesthesia without artificially reducing derived correlations. Results showed that ILC was significantly reduced in the entire DMN during 2% sevoflurane yet recovered in the posterior and anterior cingulate cortices as well as inferior parietal cortex during 1% sevoflurane. By contrast, ILC remained attenuated prefrontally in the 1% condition, which indicates uncoupling of the frontal areas of DMN during light anesthesia. These results confirm widespread anesthetic-induced cortical suppression but also demonstrate that the local connectivity of the prefrontal cortex is rapidly reduced by sevoflurane. It remains to be seen whether these alterations arise locally as a direct consequence of anesthetic action on local neurons or are driven by distant changes in oscillations and activity elsewhere in the brain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1318, 8 March 2010, Pages 110–121
نویسندگان
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