کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4327445 1614122 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serum albumin induces osmotic swelling of rat retinal glial cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Serum albumin induces osmotic swelling of rat retinal glial cells
چکیده انگلیسی

Edema in the ischemic neural tissue develops by increased vascular permeability associated with extravasation of albumin, and by glial swelling. Here, we show that bovine serum albumin acutely administered to slices of the rat retina causes swelling of glial somata under hypoosmotic conditions. The effect of albumin was dose-dependent, with half-maximal and maximal effects at 10 nM and 1 μM, respectively, and was mediated by activation of transforming growth factor-β receptor type II, oxidative stress, and the production of arachidonic acid and prostaglandins. Albumin-induced glial swelling was prevented by glutamate and purinergic receptor agonists. The data suggest that serum albumin may induce glial swelling in the presence of osmotic gradients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1317, 4 March 2010, Pages 268–276
نویسندگان
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