کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4328174 | 1614163 | 2009 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Short-term (2 to 5Â h) dark exposure lowers long-term potentiation (LTP) induction threshold in rat primary visual cortex
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کلمات کلیدی
dLGNCSDfEPSPRLSlong-term depression - افسردگی طولانی مدتcurrent source density - تراکم منبع فعلیlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP LTD - محدودdorsal lateral geniculate nucleus - هسته منشاء جانبی پشتی پشتیField excitatory postsynaptic potential - پتانسیل پستنیپتیک مزمن تحریک پذیر
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Short-term (2 to 5Â h) dark exposure lowers long-term potentiation (LTP) induction threshold in rat primary visual cortex Short-term (2 to 5Â h) dark exposure lowers long-term potentiation (LTP) induction threshold in rat primary visual cortex](/preview/png/4328174.png)
چکیده انگلیسی
Up- and down-regulation of synaptic strength (i.e., long-term potentiation, LTP, long-term depression) is thought to be the primary mechanism mediating experience-dependent plasticity of cortical networks. Recent evidence indicates that the expression of plastic changes at synapses itself is dynamic and regulated, at least in part, by the recent history of synaptic activity, a concept termed metaplasticity. Here, adult, urethane-anesthetized rats were exposed to light or dark conditions for various durations (1, 2, and 5Â h) to influence activity levels in the retinal-dorsal lateral geniculate nucleus (dLGN)-primary visual cortex (V1) pathway. Field potentials, recorded in layer IV of V1, were evoked by light flashes to the retina or single pulse electrical stimulation of the dLGN. Brief (60Â s) periods of high frequency (50Â Hz) retinal light stimulation results in an increase in visual evoked potential (VEP) amplitude in animals exposed to complete darkness for 2Â h, while VEP amplitude failed to show potentiation in animals maintained in darkness for shorter periods. Similarly, weak theta burst stimulation of the dLGN failed to induce LTP in animals maintained under continuous light, but elicited robust LTP after 5Â h of dark exposure. These data demonstrate that induction thresholds for sensory- and electrically-induced LTP in the retino-geniculo-cortical pathway of adult rats are dynamically regulated by levels of preceding sensory stimulation. Importantly, such metaplastic adjustments of plasticity in V1 can occur over time-scales significantly shorter than previously recognized.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1276, 18 June 2009, Pages 58-66
Journal: Brain Research - Volume 1276, 18 June 2009, Pages 58-66
نویسندگان
Min-Ching Kuo, Hans C. Dringenberg,