کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4328888 1614199 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dendritic spine density of posterodorsal medial amygdala neurons can be affected by gonadectomy and sex steroid manipulations in adult rats: A Golgi study
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Dendritic spine density of posterodorsal medial amygdala neurons can be affected by gonadectomy and sex steroid manipulations in adult rats: A Golgi study
چکیده انگلیسی

The posterodorsal medial amygdala (MePD) is a sex steroid-responsive area in the rat brain. The dendritic spine density of Golgi-impregnated MePD neurons were studied in: (1) adult gonadectomized (GDX) males after a short or a longer postcastration period (8 and 90 days, respectively), compared to age-matched sham operated and to intact controls; (2) adult GDX females, which received oil, estradiol benzoate (EB) alone or EB and progesterone as substitutive therapy; and, (3) EB-treated GDX females that concomitantly received saline or LY235959, a competitive antagonist of NMDA receptors, to test a possible glutamatergic mediation on the estrogen-mediated increase in spine density in this brain area. Intact males showed a higher spine density than males studied 8 days after sham operation or those in both short- and long-term GDX groups (p < 0.02), but not when compared to males at 90 days after sham operation (p = 0.12). In females, dendritic spine density increased following EB injections when compared to the oil group (p = 0.05), with an effect that was potentiated by progesterone (p < 0.01). LY235959 was not able to block the stimulating effect of EB on dendritic spines of GDX females (p > 0.2). These data provide novel evidence that MePD dendritic spines are affected by sex steroid manipulations in adult rats, GDX males had a specific spine density decrease after a long postcastration period, and estrogen (apparently independently of a NMDA receptor interaction) and progesterone have stimulatory effects on the number of dendritic spines in GDX females.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1240, 13 November 2008, Pages 73–81
نویسندگان
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