کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4329502 1614218 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats
چکیده انگلیسی

Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1221, 24 July 2008, Pages 93–97
نویسندگان
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