کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4329828 | 1614235 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Food restriction enhances peak corticosterone levels, cocaine-induced locomotor activity, and ÎFosB expression in the nucleus accumbens of the rat
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Chronic stress has been known to potentiate addictive behaviours in both human addicts and experimental animals. In the present study, chronic mild food restriction was used as a stressor to investigate its effect on the locomotor simulant effects of cocaine as well as FosB expression in the nucleus accumbens and caudate putamen. Chronic mild food restriction enhanced the locomotor response to the first cocaine injection, such that chronically food restricted animals showed a significant increase in activity upon an initial administration of 15Â mg/kg of cocaine, an effect which only became apparent in control animals after repeated injections. Food restriction also increased expression of the 35-37Â kDa isoforms of ÎFosB compared to free-fed rats. ÎFosB proteins have been previously implicated in the rewarding effects of drugs of abuse and therefore their upregulation by the prolonged stress of food restriction suggests a possible mechanism for the enhancement of addictive behaviours by stress.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1204, 14 April 2008, Pages 94-101
Journal: Brain Research - Volume 1204, 14 April 2008, Pages 94-101
نویسندگان
Jennifer A. Stamp, Rahia Mashoodh, Jackalina M. van Kampen, Harold A. Robertson,