کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4330020 1614248 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transduced PTD-BDNF fusion protein protects against beta amyloid peptide-induced learning and memory deficits in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Transduced PTD-BDNF fusion protein protects against beta amyloid peptide-induced learning and memory deficits in mice
چکیده انگلیسی

Brain-derived neurotrophic factor (BDNF) promotes the survival and differentiation of hippocampal, cortical, and basal forebrain cholinergic neurons. However, the efficacy of BDNF via peripheral (i.v.) administration is limited by the lack of transport of the neurotrophin through the blood–brain barrier (BBB) in vivo. The present study describes that the i.v. administered recombinant human BDNF (rhBDNF) conjugated with a protein transduction domain (PTD ) is able to survive and promote the growth of hippocampal neurons impaired by Aβ25–35 (10 μM) in vitro and transport through the BBB in vivo. The Morris water maze test indicated that the i.v. PTD-rhBDNF improved the spatial learning and memory of mice impaired by the aggregated Aβ25–35. The peripherally administered PTD-rhBDNF exhibited neuroprotective effects in brain and raise the possibility of delivery of the exogenous rhBDNF in treatment of the brain diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1191, 29 January 2008, Pages 12–19
نویسندگان
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