کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4330724 1614272 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neurogenesis associated with endothelin-induced cortical infarction in the mouse
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Neurogenesis associated with endothelin-induced cortical infarction in the mouse
چکیده انگلیسی

We investigated the effect of small cortical ischemic lesions, produced by intracerebral injection of the vasoconstrictor endothelin-1, on neurogenesis in the adult mouse subventricular zone. Endothelin-1 (0.5–1 μg) produced infarcts restricted to the cortex, and associated neurobehavioral deficits that largely resolved by 3 days. Bromodeoxyuridine labeling of proliferating cells in the subventricular zone was elevated by about 50% in endothelin-1-treated mice, and cells reactive for doublecortin, a marker for immature neurons, were similarly increased in number. These findings indicate that small ischemic lesions restricted to adult cerebral cortex can stimulate neuroproliferation at a distance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1167, 5 September 2007, Pages 118–122
نویسندگان
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