کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4331484 | 1614300 | 2007 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The central amygdala regulates sodium intake in sodium-depleted rats: Role of 5-HT3 and 5-HT2C receptors
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
In the present paper, we have evaluated the participation of 5-HT3 and 5-HT2C receptors in the central amygdala (CeA) in the regulation of water and salt intake in sodium-depleted rats. m-CPBG-induced pharmacological activation of 5-HT3 receptors located in the CeA resulted in a significant reduction in salt intake in sodium-depleted rats. This antinatriorexic effect of m-CPBG was reverted by pretreatment with the selective 5-HT3 receptor antagonist ondansetron. The injection of ondansetron alone into the CeA had no effect on sodium-depleted and normonatremic rats. Conversely, pharmacological stimulation of 5-HT2C receptors located in the central amygdala by the selective 5-HT2C receptor agonist m-CPP failed to modify salt intake in sodium-depleted rats. Additionally, the administration of a selective 5-HT2C receptor blocker, SDZ SER 082, failed to modify salt intake in rats submitted to sodium depletion. These results lead to the conclusion that the pharmacological activation of 5-HT3 receptors located within the CeA inhibits salt intake in sodium-depleted rats and that 5-HT2C receptors located within the CeA appear to be dissociated from the salt intake control mechanisms operating in the central amygdala.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1139, 30 March 2007, Pages 178-194
Journal: Brain Research - Volume 1139, 30 March 2007, Pages 178-194
نویسندگان
C.P. Luz, A. Souza, R. Reis, P. Mineiro, H.S. Ferreira, J.B. Fregoneze, E. De Castro e Silva,