کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4331490 1614300 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intranasal trigeminal function in subjects with and without an intact sense of smell
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Intranasal trigeminal function in subjects with and without an intact sense of smell
چکیده انگلیسی

The intranasal trigeminal system is involved in the perception of odors. To investigate the cerebral processing of sensory information from the trigeminal nerve in detail we studied subjects with and without olfactory function using functional magnetic resonance imaging. A normosmic group (n = 12) was compared with a group of anosmic subjects (n = 11). For trigeminal stimulation gaseous CO2 was used.Following right-sided stimulation with CO2 controls exhibited a stronger right-sided cerebral activation than anosmic subjects. Stronger activation was found in controls compared to anosmic subjects for the right prefrontal cortex, the right somatosensory cortex (SI), and the left parietal insula. In contrast, relatively higher activation was found in anosmic subjects for the left supplementary motor area in the frontal lobe, the right superior and middle temporal lobe, the left parahippocampal gyrus in the limbic lobe, and the sub-lobar region of the left putamen and right insula which was mostly due to a decreased BOLD signal of controls in these areas. Additional conjunction analysis revealed that activated areas common to the two groups were the cerebellum and the right premotor frontal cortex.These data suggest that the processing of the trigeminally mediated information is different in the presence or absence of an intact sense of smell, pointing towards the intimate connection between the two chemosensory systems.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1139, 30 March 2007, Pages 235–244
نویسندگان
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