کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4331527 1614303 2007 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The NMDA receptor antagonist CPP blocks the effects of predator stress on pCREB in brain regions involved in fearful and anxious behavior
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
The NMDA receptor antagonist CPP blocks the effects of predator stress on pCREB in brain regions involved in fearful and anxious behavior
چکیده انگلیسی
A 5-min unprotected exposure to a cat produces long-lasting anxiogenic effects on behavior which are NMDA receptor-dependent. Since phosphorylation of CREB is regulated by NMDA receptors and pCREB-like-immunoreactivity (lir) is increased after predator stress, we examined the effects of CPP (3-(2-carboxypiperazin4-yl)propyl-l-phosphonic acid), a competitive NMDA receptor antagonist, on predator stress-induced changes in pCREB-lir in brain areas implicated in fearful and anxious behavior. Areas examined included the amygdala, periqueductal gray (PAG), bed nucleus of the stria terminalis (BNST), anterior cingulate cortex (ACC), and dorsal medial hypothalamus (DMH). CPP blocked the predator stress-induced increase in pCREB-lir in the right lateral PAG and in several amygdala nuclei. CPP also reversed the predator stress-induced suppression of pCREB-lir in the BNST. Importantly, at least in the amygdala and PAG, the pattern of pCREB-lir was hemisphere- and AP plane-dependent. Our results suggest that several amygdala nuclei, the PAG, and the BNST, where predator stress changes pCREB-lir in a NMDA receptor-dependent manner, are candidate areas of neuroplastic change contributing to lasting changes in anxiety-like behaviors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1136, 9 March 2007, Pages 59-76
نویسندگان
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