کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4331643 1614306 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased 8-OHdG levels in the urine, serum, and substantia nigra of hemiparkinsonian rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Increased 8-OHdG levels in the urine, serum, and substantia nigra of hemiparkinsonian rats
چکیده انگلیسی

8-Hydroxy-2′-deoxyguanosine (8-OHdG), the predominant marker of oxidative DNA damage, may be a good biomarker for monitoring the progression of Parkinson's disease (PD). Unfortunately, there are no basic laboratory data examining 8-OHdG levels in animal models of PD. In this study, we demonstrate that rats lesioned with 6-hydroxydopamine (6-OHDA) in the medial forebrain bundle display significantly elevated 8-OHdG levels in urine, serum, and substantia nigra, but not cerebrospinal fluid and striatum, compared to sham controls. These increments in 8-OHdG levels were detected at 2 days, but not at 7 days after the lesion suggesting that oxidative stress is restricted to the acute phase of 6-OHDA neurotoxicity. The present results support 8-OHdG as a biomarker that may aid both in the diagnosis and in the documentation of progression in PD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1133, 16 February 2007, Pages 49–52
نویسندگان
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