کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4331643 | 1614306 | 2007 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Increased 8-OHdG levels in the urine, serum, and substantia nigra of hemiparkinsonian rats Increased 8-OHdG levels in the urine, serum, and substantia nigra of hemiparkinsonian rats](/preview/png/4331643.png)
8-Hydroxy-2′-deoxyguanosine (8-OHdG), the predominant marker of oxidative DNA damage, may be a good biomarker for monitoring the progression of Parkinson's disease (PD). Unfortunately, there are no basic laboratory data examining 8-OHdG levels in animal models of PD. In this study, we demonstrate that rats lesioned with 6-hydroxydopamine (6-OHDA) in the medial forebrain bundle display significantly elevated 8-OHdG levels in urine, serum, and substantia nigra, but not cerebrospinal fluid and striatum, compared to sham controls. These increments in 8-OHdG levels were detected at 2 days, but not at 7 days after the lesion suggesting that oxidative stress is restricted to the acute phase of 6-OHDA neurotoxicity. The present results support 8-OHdG as a biomarker that may aid both in the diagnosis and in the documentation of progression in PD.
Journal: Brain Research - Volume 1133, 16 February 2007, Pages 49–52