کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4331815 1292878 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sexual dimorphism in hybrids rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Sexual dimorphism in hybrids rats
چکیده انگلیسی

Laboratory rat strains descend from Wistar rats as a consequence of artificial selection. Previously we reported that the medial posterior division of the bed nucleus of the stria terminalis (BSTMP) was sexually dimorphic in Wistar and Long–Evans strains while the medial anterior division (BSTMA) and the locus coeruleus (LC) only showed sex differences in the ancestor Wistar strain. The lateral posterior division (BSTLP) was isomorphic in both strains. The present work studies the number of neurons in the BSTMP, BSTMA, BSTLP and LC of male and female Wistar and Long–Evans rats (F0) and their hybrid F1 and F2 generations. The BSTMP is sexually dimorphic in the F0, F1 and F2 generations while sex differences in the LC are only seen in F0 Wistar rats but not in the F0 Long–Evans or the F1 and F2 hybrid generations. Sex differences in the BSTMA are seen in F0 Wistar but not in F0 Long–Evans rats and completely disappear in the F2 generations. The number of neurons in the LC of both males and females decreased in heterozygotic individuals (F1) but increased in homozygotic (F2). However, the number of neurons in the BSTMP changes significantly over the generations, although the ratio of neurons (female/male) is stable and unaffected in homo- or heterozygosis. Thus, the mechanism that regulates the neuronal female/male ratio would be different from the one that controls the number of neurons. The facts that sex differences in the BSTMP are not affected by homo- or heterozygosis and that they are seen in several mammalian orders suggest the existence of a “fixed” type of brain sex differences in the Mammalia Class.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1123, Issue 1, 6 December 2006, Pages 42–50
نویسندگان
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