کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4332258 | 1292892 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression of prokineticin receptors in mouse cultured astrocytes and involvement in cell proliferation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Expression of prokineticin receptors in mouse cultured astrocytes and involvement in cell proliferation Expression of prokineticin receptors in mouse cultured astrocytes and involvement in cell proliferation](/preview/png/4332258.png)
چکیده انگلیسی
Effects of prokineticins (PKs), a novel family of bioactive peptides with a mitogenic action to endothelial cells of the endocrine gland and testis, on astrocytic functions were examined. Mouse cultured astrocytes expressed PK-R1 type PK receptors, while there was little expression of the PK-R2 type. PKs caused increases in astrocytic cytosolic Ca2+ levels and BrdU incorporation. Increases in Ca2+ levels by PK-2 were diminished by U73122 (a phospholipase C inhibitor). PK-induced BrdU incorporation was inhibited by U73122, GF109203 (a protein kinase C inhibitor) and PD98059 (a MEK/ERK inhibitor). These results indicate that PK receptors are expressed in astrocytes and regulate astrocytic proliferation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1112, Issue 1, 27 September 2006, Pages 65–69
Journal: Brain Research - Volume 1112, Issue 1, 27 September 2006, Pages 65–69
نویسندگان
Yutaka Koyama, Masafumi Kiyo-oka, Masakazu Osakada, Naotaka Horiguchi, Norihito Shintani, Yukio Ago, Michiya Kakuda, Akemichi Baba, Toshio Matsuda,