کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4332288 1292893 2006 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aldosterone-sensitive NTS neurons are inhibited by saline ingestion during chronic mineralocorticoid treatment
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Aldosterone-sensitive NTS neurons are inhibited by saline ingestion during chronic mineralocorticoid treatment
چکیده انگلیسی

The nucleus of the solitary tract (NTS) contains a unique subpopulation of neurons that express the enzyme 11-β-hydroxysteroid dehydrogenase type 2 (HSD2). These neurons are mineralocorticoid-sensitive and are activated in association with salt appetite during sodium deficiency. In the absence of sodium deficiency, the HSD2 neurons and sodium appetite are both stimulated by chronic mineralocorticoid administration. After 7 days of treatment with deoxycorticosterone (2 mg/day), an increased number of HSD2 neurons became immunoreactive for the neuronal activity marker c-Fos. When given access to concentrated saline (3% NaCl), deoxycorticosterone-treated rats drank eight times more than vehicle-treated rats. Saline ingestion increased neuronal activation within the medial subdivision of the NTS, but the number of c-Fos-immunoreactive HSD2 neurons was reduced. This finding suggests that the HSD2 neurons are inhibited by signals directly related to saline ingestion, and not simply by the alleviation of sodium deficiency, which does not occur during mineralocorticoid administration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1115, Issue 1, 18 October 2006, Pages 54–64
نویسندگان
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