کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4332456 | 1614315 | 2006 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Immunohistochemical analysis of subcortical white matter astroglia of infant and adult primate brains, with a note on resident neurons Immunohistochemical analysis of subcortical white matter astroglia of infant and adult primate brains, with a note on resident neurons](/preview/png/4332456.png)
An immunohistochemical analysis of brain subcortical white matter astroglia from human (infant, adult) and adult monkey (Cebus apella, Macaca nemestrina) cases without any known neurological disease, is described. Expression of synaptic vesicle-associated proteins, excitatory amino acid transporters (EAAT1 and EAAT2) and GABAA Rα2 receptor produced coarse punctate labeling in human adult white matter astrocytes. A finer, generalized, punctate labeling was observed in human infants and adult C. apella monkeys. Labeling of neuronal somata and processes with microtubule-associated proteins (MAP2a–c) and neuron nuclear (NeuN) antibodies, was also observed in subcortical white matter of humans and monkeys. Results suggest competence of subcortical white matter astroglia of the primate brain to participate in various transmitter regulatory pathways. It is also proposed that, collectively with resident neurons, they may exert some role in affecting the transfer of information that takes place through the various associational and projecting fiber systems coursing through this brain compartment.
Journal: Brain Research - Volume 1100, Issue 1, 19 July 2006, Pages 93–103