کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4332506 | 1292901 | 2006 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of heat stress on Young's modulus of outer hair cells in mice
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کلمات کلیدی
AFMOHCPTSDPOAEHspFFTF-actinCLSMfilamentous actin - actin filamentousACh - آهHeat stress - استرس گرماییAcetylcholine - استیل کولینdistortion product otoacoustic emission - انتشار محصولات octo آکوستیک محصول اعوجاجFast Fourier Transformation - تبدیل سریع فوریهPermanent threshold shift - تغییر آستانه دائمیouter hair cell - سلول بیرونی موbasilar membrane - غشاء basilarYoung's modulus - مدول یانگatomic force microscopy - میکروسکوپ نیروی اتمیconfocal laser scanning microscopy - میکروسکوپهای اسکن لیزری کانفوکالreticular lamina - ورقه ورقه ایCompound Action Potential - پتانسیل اقدام مشترکHeat shock protein - پروتئین شوک حرارتCaP - کلاه لبه دار
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of heat stress on Young's modulus of outer hair cells in mice Effects of heat stress on Young's modulus of outer hair cells in mice](/preview/png/4332506.png)
چکیده انگلیسی
Intense sound exposure causes permanent hearing loss due to hair cell and cochlear damage. Prior conditioning with sublethal stressors, such as nontraumatic sound, heat stress and restraint protects the ear from acoustic injury. However, the mechanisms underlying conditioning-related cochlear protection remain unknown. In this paper, Young's modulus and the amount of filamentous actin (F-actin) of outer hair cells (OHCs) with/without heat stress were investigated by atomic force microscopy and confocal laser scanning microscopy, respectively. Conditioning with heat stress resulted in a statistically significant increase in Young's modulus of OHCs at 3-6Â h after application, and such modulus then began to decrease by 12Â h and returned to pre-conditioning level at 48Â h after heat stress. The amount of F-actin began to increase by 3Â h after heat stress and peaked at 12Â h. It then began to decrease by 24Â h and returned to the pre-conditioning level by 48-96Â h after heat stress. These time courses are consistent with a previous report in which heat stress was shown to suppress permanent threshold shift (PTS). In addition, distortion product otoacoustic emissions (DPOAEs) were confirmed to be enhanced by heat stress. These results suggest that conditioning with heat stress structurally modifies OHCs so that they become stiffer due to an increase in the amount of F-actin. As a consequence, OHCs possibly experience less strain when they are exposed to loud noise, resulting in protection of mammalian hearing from traumatic noise exposure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1107, Issue 1, 30 August 2006, Pages 121-130
Journal: Brain Research - Volume 1107, Issue 1, 30 August 2006, Pages 121-130
نویسندگان
Michio Murakoshi, Naohiro Yoshida, Yoko Kitsunai, Koji Iida, Shun Kumano, Takashi Suzuki, Toshimitsu Kobayashi, Hiroshi Wada,