کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4332564 1292903 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mice without transcription factor KLF7 provide new insight into olfactory bulb development
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Mice without transcription factor KLF7 provide new insight into olfactory bulb development
چکیده انگلیسی

Recent genetic studies have excluded that peripheral innervation plays a substantial role in the initial outgrowth of the olfactory bulb. Mice without Kruppel-like factor 7 activity die at birth and display hypoplastic olfactory bulbs which lack peripheral innervation. Here, we report that incomplete penetrance of the mutation is responsible for partial bulb innervation in a small fraction of Klf7 null mice. Analysis of the partially innervated bulbs of mutant embryos, newborns and adult mice revealed an obligatory correlation with local restoration of laminar architecture, neuronal cell differentiation and neuronal activity. The degree of normal OB maturation in Klf7−/− OBs was proportional to the degree of peripheral innervation. These findings therefore indicate that peripheral innervation contributes to bulb maturation late in development by promoting cell morphogenesis and differentiation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1103, Issue 1, 4 August 2006, Pages 108–113
نویسندگان
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