کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4333426 1292931 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
“Fatigue” of medullary but not mesencephalic raphe serotonergic neurons during locomotion in cats
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
“Fatigue” of medullary but not mesencephalic raphe serotonergic neurons during locomotion in cats
چکیده انگلیسی

Single unit activity of presumed serotonergic neurons in the medulla [n. raphe obscurus (NRO) and pallidus (NRP)] or the mesencephalon [n. raphe dorsalis (DRN)] was recorded in adult male cats during prolonged treadmill locomotion. Treadmill speed was set at a moderate level (0.4 m/s) in order to induce long-duration locomotion. The typical time to “fatigue” (failure to keep pace, falling behind and reluctance to continue) was ∼ 40 min in both groups, at which point cats typically displayed marked panting and vocalization. The activity of DRN neurons was unchanged from baseline during the locomotion trial and during the recovery phase. By contrast, the activity of NRO/NRP neurons decreased steadily across the locomotion trial, reaching a mean decrease of ∼50% (during the first min after the treadmill was turned off). Full recovery of single unit activity to a level approximating the baseline discharge rate required 30–45 min. Possible mechanisms underlying these changes are discussed as is the role of serotonin and fatigue in human pathology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1072, Issue 1, 9 February 2006, Pages 55–61
نویسندگان
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