Drosophila modeling of heritable neurodevelopmental disorders

► 75% of identified human disease-associated genes are present in Drosophila. ► Angelman, Rett, Neurofibromatosis and Fragile X syndromes have been modeled. ► Genetics, biochemistry, anatomy, physiology and behavior have been examined. ► Drosophila has advanced understanding of UBE3A, MECP2, NF1 and FMR1 biology.