کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4334384 1294940 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chromatin remodeling in neural stem cell differentiation
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Chromatin remodeling in neural stem cell differentiation
چکیده انگلیسی

Chromatin remodeling is a dynamic alteration of chromatin structure that regulates several important biological processes. It is brought about by enzymatic activities that catalyze covalent modifications of histone tail or movement of nucleosomes along the DNA, and these activities often require multisubunit protein complexes for its proper functions. In concert with DNA methylation and noncoding RNA-mediated processes, histone modification such as acetylation and methylation regulates gene expression epigenetically, without affecting DNA sequence. Recent advances have revealed that this intrinsic regulation, together with protein complexes such as RE1 silencer of transcription/neuron-restrictive silencer factor (REST/NRSF) and switch/sucrose nonfermentable (SWI/SNF), play critical roles in neural stem cell fate determination.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Neurobiology - Volume 20, Issue 4, August 2010, Pages 408–415
نویسندگان
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