کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4334490 1294945 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Olfactory map formation in the Drosophila brain: genetic specificity and neuronal variability
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Olfactory map formation in the Drosophila brain: genetic specificity and neuronal variability
چکیده انگلیسی

The development of the Drosophila olfactory system is a striking example of how genetic programs specify a large number of different neuron types and assemble them into functional circuits. To ensure precise odorant perception, each sensory neuron has to not only select a single olfactory receptor (OR) type out of a large genomic repertoire but also segregate its synaptic connections in the brain according to the OR class identity. Specification and patterning of second-order interneurons in the olfactory brain center occur largely independent of sensory input, followed by a precise point-to-point matching of sensory and relay neurons. Here we describe recent progress in the understanding of how cell-intrinsic differentiation programs and context-dependent cellular interactions generate a stereotyped sensory map in the Drosophila brain. Recent findings revealed an astonishing morphological diversity among members of the same interneuron class, suggesting an unexpected variability in local microcircuits involved in insect sensory processing.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Neurobiology - Volume 21, Issue 1, February 2011, Pages 85–92
نویسندگان
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