کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4334601 | 1294951 | 2010 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Role of primary cilia in brain development and cancer Role of primary cilia in brain development and cancer](/preview/png/4334601.png)
The primary cilium, a hair-like extension from a cell's surface, acts as a sensory organelle to receive signals that regulate cellular behavior and physiology. Like most mammalian cells, neural progenitors and neurons have primary cilia. Recent studies show that this tiny projection plays important roles in brain development and diseases. Ciliary mutant mice show defects in brain patterning, progenitor proliferation, and specification of adult neural stem cells. Primary cilia also have dual opposing functions in the development of brain tumors. Ciliary defects are associated with genetic syndromes that frequently have neurological symptoms. Understanding the multifaceted roles that primary cilia have in brain development will provide important insights into the mechanism of brain development and diseases.
Journal: Current Opinion in Neurobiology - Volume 20, Issue 1, February 2010, Pages 58–67