کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4334702 | 1294961 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Essential and expendable features of the circadian timekeeping mechanism
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Circadian clocks control behavioral, physiological and metabolic rhythms via one or more transcriptional feedback loops. In animals, two conserved feedback loops are thought to keep circadian time by mediating rhythmic transcription in opposite phases of the circadian cycle. Recent work in cyanobacteria nevertheless demonstrates that rhythmic transcription is dispensable for circadian timekeeping, raising the possibility that some features of the transcriptional feedback loops in animals are also expendable. Indeed, one of the two feedback loops is not necessary for circadian timekeeping in animals, but rhythmic transcription and post-translational modifications are both essential for keeping circadian time. These results not only confirm additional requirements within the animal circadian timekeeping mechanism, but also raise important questions about the function of conserved, yet expendable, features of the circadian timekeeping mechanism in animals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Neurobiology - Volume 16, Issue 6, December 2006, Pages 686-692
Journal: Current Opinion in Neurobiology - Volume 16, Issue 6, December 2006, Pages 686-692
نویسندگان
Paul E Hardin,