کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4334878 1614597 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical trials in mild traumatic brain injury
ترجمه فارسی عنوان
آزمایش های بالینی در آسیب های مغزی ترومایی خفیف
کلمات کلیدی
آسیب های مغزی ترومایی خفیف ؛ کارازمایی بالینی؛ دهلیزی؛ حسی عصبی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی

BackgroundTraumatic brain injury is an increasingly prevalent injury seen in both civilian and military populations. Regardless of the mechanisms of injury, the most common sub-type of injury continues to be mild traumatic brain injury. Within the last decade, there has been tremendous growth in the literature regarding this disease entity.PurposeTo describe the obstacles necessary to overcome in performing a rigorous and sound clinical research study investigating mild traumatic brain injury. This examination begins by a consideration of changing standards for good faith open and total reporting of any and all conflicts of interest or commitment. This issue is particularly critical in mTBI research. We next examine obstacles that include but are not limited to diagnostic criteria, inclusion/exclusion criteria, source of injury, previous history of injury, presence of comorbid conditions and proper informed consent of participants. Frequently, multi-center studies are necessary for adequate subject accrual with the added challenges of site coordination, data core management and site specific study conduct. We propose a total reversal to the traditional translational research approach where clinical studies drive new concepts for future basic science studies.ConclusionsThere have been few mild traumatic brain injury clinical trials in the literature with treatments/interventions that have been able to overcome many of these described obstacles. We look forward to the results of current and ongoing clinical mild traumatic brain injury studies providing the tools necessary for the next generation of basic science projects.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroscience Methods - Volume 272, 15 October 2016, Pages 77–81
نویسندگان
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