Wireless implantable micro-stimulation device for high frequency bilateral deep brain stimulation in freely moving mice

► This paper describes a new light-weight wireless implantable micro stimulator device for mice. ► The device delivers biphasic pulse patterns to two individual electrode pairs, mimicking the clinical situation. ► Bench-top validation shows that this device reliably delivers continuous bilateral stimulation. ► In vivo implementation indicates that the wireless implantable stimulator in mice does not restrict the animal's mobility and hygiene (grooming behavior). ► As previously shown by others, our in vivo results showed a marked increase in c-fos expression around the electrode tip in the nucleus accumbens in mice following DBS at 100 μA.