Design of an in-dwelling cannula for convection-enhanced delivery

Failures of recent convection-enhanced delivery (CED) trials have underscored the need for improved CED cannulae. This study presents a novel in-dwelling cannula targeted for use in upcoming neuro-oncological or neurodegeneration trials. The cannula is reflux-resistant and easily integrated into clinical workflows. The cannula was evaluated in non-human primate CED studies performed with magnetic resonance imaging (MRI) to validate the effectiveness and safety of the infusion.

Research highlights▶ A novel cannula for convection-enhanced delivery (CED) trials is presented. ▶ The cannula is in-dwelling, MRI-compatible and reflux-resistant. ▶ The cannula is designed for use in upcoming trials in neuro-oncology and neurodegeneration. ▶ The cannula performance is validated in non-human primate infusions.