Modulus and direction of the neural current vector identify distinct functional connectivity modes between human MT+ areas

Reconstruction of neural current sources from magnetoencephalography (MEG) data provides two independent estimates of the instantaneous current modulus and its direction. Here, we explore how different information on the modulus and direction affects the inter-hemisphere connectivity of the human medial temporal complex (hMT+). Connectivity was quantified by mutual information values of paired time series of current moduli or directions, with the joint probability distribution estimated with an optimized Gaussian kernel. These time series were obtained from tomographic analysis of single-trial MEG responses to a visual motion stimulus. With a high-contrast stimulus, connectivity measures based on the modulus were relatively strong in the prestimulus period, continuing until 100 ms after stimulus onset. The strongest modulus connectivity was produced with a long lag (19 ms) of the right hMT+ after the left hMT+. On the other hand, connectivity measures based on direction were relatively strong after 100 ms, with a short delay of less than 6 ms. These results suggest that nonspecific and probably indirect communication between the homologous areas is turned, by the stimulus arrival, into more precise and direct communication through the corpus callosum. The orientation of the estimated current vector for the strong connectivity can be explained by the curvature of the active cortical sheet. The temporal patterns of modulus and directional connectivity were different at low contrast, but similar to those at high contrast. We conclude that the modulus and direction indicate distinct functional connectivity modes.

Research highlights▶ Indirect communication between the hMT+ areas is turned into direct one by stimulus. ▶ Curvature of cortical sheet explains orientation of current vector for connectivity. ▶ Modulus and direction of current vector indicate distinct connectivity modes.