کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4335565 1295167 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Characterization of the hemodynamic response in the rat lumbar spinal cord using intrinsic optical imaging and laser speckle
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Characterization of the hemodynamic response in the rat lumbar spinal cord using intrinsic optical imaging and laser speckle
چکیده انگلیسی

Quantifying spinal cord functions is crucial for understanding neurophysiological mechanisms governing the intact and the injured spinal cord. Intrinsic optical imaging (IOI) and laser speckle provides measures of deoxyhemoglobin (HbR) and oxyhemoglobin (HbO2) concentrations, blood volume (BV) and blood flow (BF) at high spatial and temporal resolution. In this study we used IOI and laser speckle to characterize the hemodynamic response to neuronal activation in the lumbar spinal cord of anaesthetized rats (N = 9). We report consistent temporal variations of HbR, HbO2, BV and BF located ipsilaterally at L3–L5. Responses were significantly higher when stimulation intensity was increased. Vascular changes extended several millimetres from the epicenter, supporting the venous drainage observed in functional magnetic resonance imaging studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroscience Methods - Volume 191, Issue 2, 30 August 2010, Pages 151–157
نویسندگان
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