کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4336230 1295200 2009 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A new method of spike modelling and interval analysis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
A new method of spike modelling and interval analysis
چکیده انگلیسی
Here we develop a new model of spike firing, based on the leaky integrate and fire model, modified to simulate afterpotentials. We also develop new analysis techniques, applying these to recorded and model generated data in order to make a comparative analysis and develop the model as a hypothesis for the functional components of the neuron. The model is based in this first instance on hypothalamic oxytocin neurons. We demonstrate how model parameters and cell properties relate to features observed in inter-spike intervals histograms, and the limits of these in being able to detect patterning features in spike recordings. A new technique, spike train analysis, is able to detect previously unobserved patterning, showing a dependence of spike intervals on previous firing activity. This effect is reproduced in the model by adding the small amplitude but long lasting after hyper-polarising potential (AHP). A fit measure based on log likelihood is used to compare model generated data to recorded spike intervals, taking account of interval dependence on previous activity. This measure is used with the simplex multiple parameter search algorithm to develop an automated method for fitting the model to recorded data.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroscience Methods - Volume 176, Issue 1, 15 January 2009, Pages 45-56
نویسندگان
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