کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4336444 1295213 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduction of dominant or submissive behaviors as models for antimanic or antidepressant drug testing: Technical considerations
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Reduction of dominant or submissive behaviors as models for antimanic or antidepressant drug testing: Technical considerations
چکیده انگلیسی

Technical variants of mania and depression models that were based on dominant–submissive relationships (DSR) have been analyzed and compared in the present paper. In these paradigms, one animal of a pair developed the behavioral trait of dominance while the other submissiveness in a food competition test after repeated interactions in a specially designed apparatus. Data collection methods and timelines have been compared in variants of the DSR-based models. In addition, different selection criteria to assign dominant or submissive status to animals and two different scoring systems were evaluated. The importance of the selection criteria for DSR stability has been emphasized. Our data showed that (1) only animals selected with the strict criteria form clear dominant and submissive relationships that hold throughout the study period, (2) submissive animals were influenced by fluoxetine and dominant animals were influenced by sodium valproate similarly in pairs scored by human observer and by a video-tracking system. These studies indicate that the model variant using stringent selection criteria and automatic scoring was the most reliable for use in depression-related studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroscience Methods - Volume 165, Issue 2, 30 September 2007, Pages 175–182
نویسندگان
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