A new probe to monitor the effects of drugs on local field potentials

We describe a new device with which microdialysis can be combined with bipolar local field potential (LFP) recordings. The device consists of a microdialysis probe with two ultra-thin electrical wires located within its tip. The device can be used to monitor LFPs with differential recording methods before, during, and after local application of drugs by reverse microdialysis, while concomitantly sampling biochemical constituents from the area of recording.