Neuromedin U receptor 2 knockdown in the paraventricular nucleus modifies behavioral responses to obesogenic high-fat food and leads to increased body weight

• Knock down of NMUR2 in the PVN stimulates intake of an obesogenic diet resulting in increased body weight.
• NMUR2 signaling in the PVN regulates dietary preference.
• NMUR2 knockdown in the PVN increases binge-type eating behavior.

Neuromedin U (NMU) is a highly conserved neuropeptide which regulates food intake and body weight. Transgenic mice lacking NMU are hyperphagic and obese, making NMU a novel target for understanding and treating obesity. Neuromed