Cellular and ultra structural evidence for cytoskeletal localization of prolyl endopeptidase-like protein in neurons

► PREPL deficiency affects the abundance of cytoskeletal proteins. ► PREPL is co-localized with cytoskeletal proteins in mouse primary neurons. ► PREPL is present in brain regions important for motor function, memory and arousal. ► In Alzheimer's disease, the cellular localization of PREPL is altered. ► The physiological functions of PREPL are associated with the cytoskeleton.