Development of the microglial phenotype in culture

- Morphological, molecular and functional aspects of cultured microglia were studied.
- TI values revealed the evolving microglial morphology during culturing.
- Microglia with TI < 3 were more active in phagocytosing than the ramified forms.
- HLA DP, DQ, DR-positive microglia were exclusively ameboid.
- CD11b/c-labeled microglia were typically less ramified than the Iba1-labeled cells.