کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4338018 | 1614837 | 2013 | 9 صفحه PDF | دانلود رایگان |

Interaction between steroid sex hormones and brain-derived neurotrophic factor (BDNF) is a common feature of vertebrate brain organization. The avian song control system provides an excellent model for studying such interactions in neural circuits that regulate song, a learned sensorimotor behavior that is often sexually dimorphic and restricted to reproductive contexts. Testosterone (T) and its steroid metabolites interact with BDNF during development of the song system and in adult plasticity, including the addition of newborn neurons to the pallial nucleus HVC and seasonal changes in structure and function of these circuits. T and BDNF interact locally within HVC to influence cell proliferation and survival. This interaction may also occur transsynpatically; T increases the synthesis of BDNF in HVC, and BDNF protein is then released on to postsynaptic cells in the robust nucleus of the arcopallium (RA) where it has trophic effects. The interaction between sex steroids and BDNF is an example of molecular exploitation, with the evolutionarily ancient steroid-receptor complex having been captured by the more recently evolved BDNF. The functional linkage of sex steroids to BDNF may be of adaptive value in regulating the trophic effects of the neurotrophin in sexually dimorphic and reproductively relevant contexts.
► I show that sex steroid hormones interact with BDNF in the avian song control system.
► I show that steroid–BDNF interactions are important for sexually dimorphic development.
► I show that steroid–BDNF interactions are important for adult neurogenesis and seasonal plasticity.
► I show that these interactions may occur transsynaptically as well as locally.
► I show that the phylogenetically ancient steroid-receptor complex captured the more recently evolved neurotrophins.
Journal: Neuroscience - Volume 239, 3 June 2013, Pages 115–123