Adolescent binge drinking increases expression of the danger signal receptor agonist HMGB1 and toll-like receptors in the adult prefrontal cortex

► Adolescent binge drinking upregulates danger signal receptors in adult brain. ► Binge ethanol exposure during adolescence increases HMGB1 in adult brain. ► Adolescent binge ethanol exposure leads to long-term reversal learning deficits. ► Alcohol-induced activation of danger signaling contributes to behavioral deficits.